tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate
tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate
CAS: 329004-08-2
Molecular Formula: C17H27N3O2
tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate - Names and Identifiers
| Name | tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate |
| Synonyms | LogP OTAVA-BB 1202440 4-[2-(4-Boc-piperazin-1-yl)ethyl]aniline [4-[2-(4-BOC-PIPERAZIN-1-YL)ETHYL]PHENYL]AMINE tert-butyl 4-(4-aminophenethyl)piperazine-1-carboxylate tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate 4-(4-aminophenethyl)piperazine-1-carboxylic acid tert-butyl ester |
| CAS | 329004-08-2 |
| InChI | InChI=1/C17H27N3O2/c1-17(2,3)22-16(21)20-12-10-19(11-13-20)9-8-14-4-6-15(18)7-5-14/h4-7H,8-13,18H2,1-3H3 |
tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C17H27N3O2 |
| Molar Mass | 305.42 |
| Density | 1.105g/cm3 |
| Boling Point | 433.3°C at 760 mmHg |
| Flash Point | 215.9°C |
| Vapor Presure | 1.04E-07mmHg at 25°C |
| Refractive Index | 1.553 |
tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate - Introduction
tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate is a compound whose chemical name is tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-cartridge.
The compound has the following properties:
1. Appearance: white crystalline solid
2. Molecular formula: C18H28N2O3
3. Molecular weight: 320.43g/mol
4. Melting Point: 78-81 ° C
5. Boiling Point: 537.3 ° C (expected)
The compound is mainly used in medicine and chemical research. Specific uses include but are not limited:
1. Drug intermediates: It is an important intermediate for the synthesis of certain drugs, such as antidepressants, sedatives, etc.
2. Chemical Research: as a starting material for organic synthesis, for the synthesis of various compounds.
The method for preparing the tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate is as follows:
1.4-aminoacetophenone is reacted with Boc-piperazinol to generate 4-(Boc-piperazinyl) ethanone with Boc-protecting group.
2. The compound obtained in the previous step is reacted with P-hydroxybenzaldehyde to generate 4-[2-(4-Boc-piperazinyl) ethyl] benzophenone.
3. Finally, add the product of the previous step to the tert-butyl product to generate the final tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate.
Regarding the safety information of this compound, please note the following:
1. The compound may be irritating to the eyes, skin and respiratory system, so pay attention to avoid contact when using it.
2. In the process of operation, should wear appropriate protective equipment, such as gloves, protective glasses and masks.
3. Comply with the safety operation procedures of the laboratory and operate under suitable conditions.
4. The compound may be harmful to the environment, should be reasonable disposal of waste.
The compound has the following properties:
1. Appearance: white crystalline solid
2. Molecular formula: C18H28N2O3
3. Molecular weight: 320.43g/mol
4. Melting Point: 78-81 ° C
5. Boiling Point: 537.3 ° C (expected)
The compound is mainly used in medicine and chemical research. Specific uses include but are not limited:
1. Drug intermediates: It is an important intermediate for the synthesis of certain drugs, such as antidepressants, sedatives, etc.
2. Chemical Research: as a starting material for organic synthesis, for the synthesis of various compounds.
The method for preparing the tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate is as follows:
1.4-aminoacetophenone is reacted with Boc-piperazinol to generate 4-(Boc-piperazinyl) ethanone with Boc-protecting group.
2. The compound obtained in the previous step is reacted with P-hydroxybenzaldehyde to generate 4-[2-(4-Boc-piperazinyl) ethyl] benzophenone.
3. Finally, add the product of the previous step to the tert-butyl product to generate the final tert-butyl 4-[2-(4-aminophenyl)ethyl]piperazine-1-carboxylate.
Regarding the safety information of this compound, please note the following:
1. The compound may be irritating to the eyes, skin and respiratory system, so pay attention to avoid contact when using it.
2. In the process of operation, should wear appropriate protective equipment, such as gloves, protective glasses and masks.
3. Comply with the safety operation procedures of the laboratory and operate under suitable conditions.
4. The compound may be harmful to the environment, should be reasonable disposal of waste.
Last Update：2024-04-09 21:00:56
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